Sniffing out a marker of early Alzheimer disease

Sniffing out early reaction intermediates.

P owerful tools for identifying reaction intermediates and byproducts of chemical reactions are crucial for the development of high-yield chemical syntheses, not only for testing theoretical mechanistic models and calculations, but also to obtain improved understanding of reaction mechanisms during trial experiments. This will enable more efficient steering toward optimum yields for a variety o...

Sniffing Out the Right Address

Olfactory systems in organisms ranging from invertebrates to mammals distinguish between odors using an array of olfactory neurons that express different olfactory receptors—usually just one receptor in a given neuron. Since an organism’s genome can encode hundreds of olfactory receptors, researchers have struggled to understand how a single olfactory neuron decides which receptor to express. I...

Sniffing out Parkinson’s disease Psychophysical and neurophysiological studies of impaired olfactory information processing in Parkinson’s disease

“Noncognitive” symptoms of early Alzheimer disease

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Protein Kinase Cε in the Platelet and Hippocampal Tissue as a Diagnostic Biological Marker in Alzheimer Disease

Introduction: Alzheimer disease (AD) is a neurodegenerative disorder characterized by the progressive loss of memory and other cognitive functions. Protein kinase Cε (PKCε) is an isoform that most effectively suppresses amyloid beta (Aβ) production and synaptic loss. Methods: In this study, spatial learning and memory for treated rats were evaluated by the Morris water maze test. The activity ...